From clinician to researcher to administrator — Dr. Melissa Forgie’s career touches just about every area of healthcare as we know it. She’s treated patients, conducted practice-changing research, and now, as Vice President of Medical Education at The Ottawa Hospital, Dr. Forgie is shaping the next generation of healthcare providers.

With an M.D. from uOttawa, two specialty certifications — in internal medicine and hematology — from the Royal College of Physicians and Surgeons of Canada, a fellowship in thromboembolic diseases, and a Master of Clinical Epidemiology, Dr. Forgie has been a part of The Ottawa Hospital since 1995, when she first joined as a medical consultant, later taking on a clinical investigator role doing research into thrombosis — when blood clots block veins or arteries.

Dr. Forgie took some time to tell us about how her career has been shaped by falling in love with internal medicine, going on maternity leave, and hope for the exciting possibilities of the new campus development of The Ottawa Hospital.

Q: Can you tell us a little bit about your early years and where you grew up?

A: I was born in Washington, D.C., to a Scottish father and a British mother. My father was a military physician at the Walter Reed Military Hospital at the time I was born, and then I grew up all over the place. My formative years were in Germany, but I was a Canadian citizen by grade school. I was raised with all the Scottish traditions though — I love bagpipes, oatmeal, and wear the family tartan.

Q: How did you decide you want to pursue medicine?

“I never wanted to be anything else. From the moment I could say the word, I wanted to be a doctor.”

— Dr. Melissa Forgie

A: My grandfather was a doctor, so I’m a third generation Dr. Forgie. Some of my earliest, most vivid memories are of going on ward rounds with my father in Germany at the military hospital there. This is going to sound very nerdy, but I remember sitting in Germany with headphones on, listening to classical music and reading my father’s medical journals. His bedtime stories to me were about the parts of the eye. I’ve just always been a real sponge for anything medical.

Dr. Melissa Forgie and her father in their family tartan.

Q: Why did you choose internal medicine and hematology as your specialities?

A: For internal medicine, I was a third-year med student at the University of Ottawa, and it was back in the days when putting the student on the spot as initiation was acceptable. I remember one of the staff threw me into a room at the Civic and said, “you have two minutes to make the diagnosis.” Absolutely that would be unacceptable behaviour with a med student nowadays, but fortunately I managed to come up with the diagnosis, and the rest is history. I just really liked the challenge of no one knowing what’s going on and multisystem disease and illness, so I gravitated towards that.

Then, hematology appealed to the science nerd in me. It’s a speciality where there’s the lab and basic science happening right at the bedside. You’re looking at the molecular basis of disease in the patients.

Q: What were your first years practicing like?

A: I started off in a very heady, stimulating, awesome time back in the mid-to-late ’90s — we were literally doing practice-changing research. It was the early days of thrombosis research. I was the first thrombosis fellow in Ottawa way back in the dark ages, and now we’re the biggest thrombosis fellowship program in the world.

But there were some glass ceilings. I was the first woman in Canada with a career-funded research grant through the Medical Research Council to take a maternity leave. They had no maternity leave policy back in those days. I had to fight some pretty intense battles to get these policies in place.

They were challenging and interesting times, but lots of fun.

Tim Kluke, Dr. Melissa Forgie, and Cameron Love at The Ottawa Hospital’s President’s Dinner, held at the EY Centre Tuesday, June 13, 2023.

Q: How did you get involved in medical education?

A: I was having a lot of fun on the research track; this would have been in the mid-to-late ’90s. To be a principal investigator then, you had to be travelling all over the world, and that’s how you got your grants, by giving public presentations and attending investigator meetings.

I remember exactly when I realized I couldn’t do this anymore. I was pregnant with my second child, it was a snowstorm, I was driving from an airport to an investigator meeting, and I just thought, “I can’t do this. I’m miserable, and I’m away from my daughter.”

I thus made the difficult decision to step away from being a clinician investigator. I was already doing some teaching at that point, so I was straddling these education and administration roles, and it was a steppingstone into medical education and advocacy for learners. The rest is history as I moved up the medical education hierarchy, and my current job — Senior Vice Dean and Vice President Medical Education — is without doubt, the best job in the world. You can advocate for all learners and make change.

There’s a real link between the learning environment and patient outcomes. We joke that specialists don’t just emerge from the uterus as fully trained physicians. There’s a whole process, and we know the better the learning environment is, the better physicians they’ll be. It all boils down to my most important driving force, which is the patient.

“Clinical care looks after patients today; education is looking after patients tomorrow.”

— Dr. Melissa Forgie

Q: What makes The Ottawa Hospital stand out on the international stage?

A: I can mostly speak to my very niche areas, which are thrombosis and education.

Back when I started, I went to a course at Harvard right before my Royal College exams, and when I showed up, they said, “You’re from Ottawa, you’re one of them cowboys who treats pulmonary embolism patients as outpatients!”

Even now, when we as thrombosis specialists travel, everywhere else in the world is sort of like, “Oh my gosh, you’re from Ottawa?”

“In Ottawa, we’re heavy hitters in medical education.”

— Dr. Melissa Forgie

We are uniquely poised in Ottawa in that we have a large adult hospital, a children’s hospital, and a number of specialty hospitals. So, we have a rich learning and teaching experience, we have depth and breadth, and we have some unbelievably well-known medical education researchers.

There are so many pockets of excellence where we’re absolutely world leaders in clinical care, clinical research, and education. We’ve got it going on, but people just don’t know about it. We don’t blow our own horn; I think that’s a bit of an Ottawa thing.

Q: What will a new, state-of-the-art health and research campus to replace the aging Civic campus mean for your patients?

A: For me, what resonates is that the technology will profoundly improve patient care. From virtual reality (VR) to artificial intelligence (AI) — it’s all really inspiring.

I also love the sustainability piece, the planetary health piece. Healthcare provision is one of the most wasteful industries on the planet, and it’s where we really need to up our game. I’m hopeful that this will be a huge part of the infrastructure in terms of the capital and basic operations.

What also excites me is that this will be a leading facility that will attract and retain top talent.

Q: Where would we find you when you’re not at work?

A: I do some volunteering for disadvantaged youth and other not-for-profit board work, and I’m also a big animal rights person.  I used to have 15 pets because we would rescue animals. The list is a bit smaller now, but we still have a fair array of beasts. People joke that I should have been a vet.

I have two adult children; my daughter is a lawyer on Wall Street living the dream, and my son is an officer in the Canadian Armed Forces currently deployed for the Ukraine war effort.

My husband’s a lawyer, and I met him in Grade 4. I was the weird kid with a funny accent and funny clothes. He took me under his wing, and the rest is history. We can have three-hour conversations with one look. We live on a five-acre property out in the woods; I love to wander around my beautiful, wooded paradise with my dogs, just 20 minutes from the hospital.

Dr. Melissa Forgie snowshoeing with her dogs.
Dr. Melissa Forgie and her husband.

When Dr. Dean Fergusson’s research career began 25 years ago, the Canadian blood system was robust and transfusions were very safe — and both are still true today. But the field was also ripe for research, with a multitude of unanswered questions.

During his time at The Ottawa Hospital, Dr. Fergusson has answered some of these questions with his revolutionary research. One of his studies, for example, showed that a cheaper, generic drug used to prevent blood loss during surgery is actually safer than a much preferred and costlier version. Another study showed fresher blood was no better, and perhaps even somewhat harmful, compared to older stored blood. Both discoveries transformed our understanding of blood and transfusions.

Dr. Fergusson’s research has tangible outcomes; it has already saved thousands of lives and improved blood transfusions for millions of people around the world. Now, he’s training the next generation of researchers to make sure the important questions keep getting asked — and answered.

Q: Can you tell us a little bit about your childhood?

A: I was born in North Vancouver, but I grew up all over B.C. because my dad was in banking. I spent most of my childhood outdoors, doing a lot of hiking and fishing and sports. It certainly gave me an appreciation for nature and the diverse geography of B.C. I also played soccer from when I was young and into my twenties, which led to coaching my three sons. I was a weird kid in that I loved school, especially the sciences.

“Through my upbringing, my dad and my mom would say, ‘If you’re going to do something, do it well.’ All that stuck with me.”

— Dr. Dean Fergusson

Looking back, trying to put your life together, you see little things that are still with you today. For me, that would be a love of sciences and the outdoors.

Dr. Dean Fergusson and his wife.

Q: How did you wind up pursuing blood transfusion research?

A: I got into McGill’s political science and economics program and fell in love with health policy. I met my future wife there and we moved to Ottawa in the early ’90s. I was trying to get into the government, but I was getting nowhere. On the advice of a good friend, I applied to the Master’s of Health Administration at the University of Ottawa. It was during a course in epidemiology that I knew it was what I wanted to do. It was taught by Dr. Robert Cushman, who was Ottawa’s medical officer of health from 1996 to 2005. It was his passion and teaching style that made me realize this is what I want to do. I finished up my masters in a couple years and started applying for jobs in the hospital-based research field. I was fortunate enough to be hired right out of my masters at The Ottawa Hospital, working with Drs. Andreas Laupacis and Ian Graham.

It was just an amazing, amazing experience. I couldn’t ask for two better mentors. As they say, the rest is history! They encouraged me to go on to do a PhD in epidemiology focusing on blood transfusion research because there were so many unanswered questions. The recipe was there for success: getting my PhD, learning more elaborate methods of design and analysis, and applying it to a field that was ripe for research — the transfusion medicine field. The marriage of these led to a productive and rewarding career.

Dr. Dean Fergusson’s research discoveries have transformed our understanding of blood and transfusions.

Q: What do you find so exciting about research?

A: Going back to high school chemistry and physics classes, I was always fascinated that to carry out an experiment properly, you had to follow it to a T — there’s a recipe, a method to the madness, or else the experiment won’t work. Through my upbringing, my dad and my mom would say, “If you’re going to do something, do it well.” All that stuck with me. The beautiful thing about research is you can bring clarity to important questions, but you only bring that clarity if you do it well, and that includes getting the questions right. Drs. Laupacis and Graham instilled in me getting the question right and answering it in the right manner. What I love about research is the ability to make a real difference. If you have a question that needs answering, and you answer it, you can help define practice or change practice.

Q: What does receiving the Grimes Career Achievement Award mean to you?

A: It means a ton to me, to be frank. I think it’s a recognition of a career of making a difference. My peers nominated me and supported the application — that’s precious to me. On a personal note, I knew Dr. J. David Grimes when I first started my career. Dr. Grimes was still involved with the Loeb Research Institute, which is where I started, and he was a phenomenally kind and gentle man, a gentle leader. It definitely brought back memories.

Dr. Dean Fergusson at Anfield Stadium.

Q: What do you get up to when you’re not in the lab?

A: My interests are definitely travel, and specifically canoe camping. My one regret is not knowing about Algonquin Park earlier, when we first arrived in Ottawa — it’s a treasure. I also enjoy long walks and hikes on rural trails with our blue heeler.

I’m also a big live music guy, preferably in smaller venues. I love just going out and seeing acts I haven’t seen before. You get to know the venues in the city and nearby towns. One of our favourite acts is the Skydiggers out of Toronto. The wealth of talent that comes through, the raw talent, is incredible.

It’s also worth mentioning I’m still a huge football (or soccer) fan, and I cheer on Liverpool.

Q: What’s next for you, personally and professionally?

A: Professionally, I’ve got a couple big studies. One is wrapping up on whether having female or male donors makes a difference for transfusion recipients. We randomized 9,000 patients at The Ottawa Hospital who got transfusions exclusively from male or female donors. Animal and observational work shows there could be differences related to hormone levels. The results will be out soon.

Personally, I’m waiting for the pandemic to be over so I can travel more. I do miss that. In the meantime, I love watching my family grow and their careers grow.

Q: Lastly, what stands out about your work at The Ottawa Hospital?

Looking back, it’s the mentorship. It instilled in me the importance of having your champions — and I love having that role myself now. The Ottawa Hospital environment has been an exceptional place to work, and it’s really what’s kept me here. You get other offers in places like Toronto, Montreal, or Vancouver, but it’s such a great environment, and there’s still more to do here.

“There is still so much more potential at The Ottawa Hospital. With our people, our ideas, and the outstanding clinical and research environment, we can impact the lives of patients and their families around the world.”

— Dr. Dean Fergusson
Dr. Natasha Kekre is a hematologist and associate scientist at The Ottawa Hospital.

When Dr. Natasha Kekre isn’t taking home the Medicine Ball trophy at our Dancing with the Docs fundraiser, she’s balancing her three different roles at The Ottawa Hospital. In September 2023, she was named the Research Chair in Advanced Stem Cell Therapy in addition to being a hematologist and scientist. She is also an associate professor at the University of Ottawa. Her research focusses primarily on blood cancers, and specifically on early phase clinical trials, oncolytic virus therapy (in which viruses are used to infect and destroy cancer cells), and building a Canadian CAR T-cell platform (chimeric antigen receptor T-cells are immune cells engineered to kill cancer cells).

Q: What is something unusual or surprising about the field of hematology?

A: Hematology is unique because we get to work with a lab as well as with patients. The diagnostics for hematology rely on our expertise in the lab, and this is different than other specialties. I can actually go to the lab and make a diagnosis by looking at a patient’s blood under the microscope.

Q: How have the treatment options for blood cancers changed since you first started?

A: Treatments called immune therapies are now giving us more arsenal against blood cancers. Therapies like checkpoint inhibitors and CAR T-cells have helped us improve outcomes for patients with blood cancers.

Q: What is The Ottawa Hospital doing in hematology research that is exciting or groundbreaking?

A: We are the one facility in the country that can make clinical-grade viruses for trials. This allows us to be a leader in the field of CAR-T therapy, which relies on this virus manufacturing to provide the genetic material needed for T-cell coding.

Q: As a hematologist, why did you choose to work at The Ottawa Hospital?

A: There are phenomenal scientists in Ottawa who made me choose this hospital for my career. Dr. Harold Atkins for example, world leader in stem cell transplant for multiple sclerosis, and Dr. John Bell, world leader in virus research and manufacturing, have been two of my mentors and collaborators. It is this collaborative approach to clinical trials and research that motivated me to join The Ottawa Hospital.

Q: How does having the most technologically advanced facility make a difference to your work at The Ottawa Hospital?

A: I would not be able to lead and run CAR-T clinical trials in Ottawa if we did not have the ability to make these clinical-grade viruses. Very few people in Canada get to run clinical trials early in their career, trials that actually have the potential to save lives, but the technology here in Ottawa has given me that opportunity.

Q: You worked on Owen Snider’s case. What made that case challenging or unique?

A: Owen, like some of my patients, was out of options for his cancer. This is unfortunate and always leads to very difficult conversations with patients and their families. What was unique here was that I had a clinical trial that could benefit someone like Owen, and thankfully he was able to get CAR T-cells on the trial.

Owen and Judith Snider. Owen was treated by Dr. Kekre for his lymphoma.
Owen and Judith Snider.

Q: How does community support for research ultimately help patients?

A: Trials like CAR T-cells are highly expensive and complicated to run, and they require significant funding for infrastructure and manufacturing — aspects of a trial that are generally not well-funded. This is why we rely so heavily on community support to help us actually reach our goal of opening trials and treating patients.

Q: What would we find you doing when you aren’t at the hospital?

A: You would find me cooking or baking with my daughter. We love to cook and make fancy meals and desserts, that’s how I occupy my weekends when I’m not working!


The Ottawa Hospital is a leading academic health, research, and learning hospital proudly affiliated with the University of Ottawa.